Packers Game Sunday: Packers vs. 49ers odds and prediction for NFL Week 3 game

The Packers face a tough challenge in Week 3 against the 49ers.

After getting back on track on Monday night, the Green Bay Packers travel to the west coast on a short week to visit the undefeated San Francisco 49ers.

It will be an opportunity to build on what they achieved in Week 2 against the Detroit Lions, but the challenge will be far greater against a talented 49ers team.

It will be another primetime game for the Packers, with the game set to be played on Sunday Night Football. Kickoff is at 7:20 p.m. CT on Sunday, Sept. 26 from Levi’s Stadium.

Packers vs. 49ers Odds Week 3

According to WynnBET, the Packers enter this game as 3.5-point underdogs with an over/under of 49.5 points. Green Bay is +155 on the money line, San Francisco -185. Despite an impressive win last week, WynnBET expects this to be a tough challenge for Matt LaFleur’s team on the road.

Packers vs. 49ers Prediction Week 3

Yes, Green Bay won at Levi’s Stadium last season, but San Francisco was without many of its key starters. That won’t be the case on Sunday night. The Niners look back to their best and very much in contention in the NFC West, arguably the league’s toughest division.

Joe Barry’s defense did improve in the second half against the Lions, but their performance in their opening six quarters of the 2021 season is cause for concern. The Packers have struggled to slow down Kyle Shanahan’s offense in the past, and the same could be true on Sunday night.

Unless Green Bay gets off to a fast start and can run the ball with success, it’s going to be another long evening on the west coast. On a short week, this feels like a game the Packers will struggle in, unfortunately. Not for the first time, the 49ers win this matchup.

Prediction: 49ers 33-24

Make your pick now on WynnBET.